Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain

Table 3

Description of the genotyped SNPs and results for association with SNCA expression.

SNP	Position (Genome Build 36.3)	Gene	Familial PD GWAS 𝑃-values [32]	SNCA expression estimate	SNCA expression min 𝑃-value	Sample^a/; Transcript^b/Model^c	MAF in expression samples	A1/A2
rs1560488	90,444,858	GPRIN3	0.12	0.235	0.048	C/T/rec	0.229	T/C
rs4106153	90,463,499	intergenic	9.18 × 10^−5	−0.048	0.206	All/T/add	0.196	C/A
rs1504489	90,477,611	intergenic	8.42 × 10^−5	−0.124	0.089	PD/T/rec	0.425	T/G
rs924033	90,654,576	intergenic	0.02	0.165	0.041	C/FL/add	0.067	G/T
rs356229	90,825,620	intergenic	5.48 × 10^−5	−0.099	0.247	C/FL/rec	0.360	C/T
rs356219	90,856,624	intergenic	*2.24 × 10^−6	0.053; 0.040	0.062; 0.085	PD/FL/add; All/FL/add	0.391	G/A
rs356188	90,910,560	SNCA	8.41 × 10^−5	0.062	0.063	C/FL/add	0.278	C/T
rs3775478	91,061,863	MMRN1	6.07 × 10^−5	0.035; 0.017	0.672; 0.672	C/T/add; All/FL/add	0.090	G/A

*imputed SNP result for published SNCA eSNP [13, 33].
^aPD-Case, C-Control, All-Combined sample.
^bFL-full length or T-total.
^cadditive or recessive SNP model.
A1-minor allele, A2–major allele.