The Prevalence of Fatigue Following Deep Brain Stimulation Surgery in Parkinson's Disease and Association with Quality of Life

Table 1

Comparison of clinical characteristics in high and low fatigue patients. Data reported as mean (standard deviation).

	Total (𝑛=44)	Low fatigue (FSS < 4) (𝑛=19)	High fatigue (FSS ≥ 4) (𝑛=25)	𝑃 value
Age (years)	63.3 (10.0)	61.5 (11.4)	64.7 (8.8)	0.32
Gender (% male)	86%	84%	88%	0.71*
DBS target	STN (30)	STN (14)	STN (16)
	GPI (10)	GPI (3)	GPI (7)	0.59**
	VIM (4)	VIM (2)	VIM (2)
Disease duration (years)	15.5 (5.5)	17.1 (6.0)	14.1 (11.8)	0.10
Months after DBS	26.1 (20.9)	27.3 (25.8)	25.3 (12.4)	0.81
Hoehn and Yahr (on)	2.5 (0.7)	2.5 (0.5)	2.5 (0.7)	0.92
UPDRS motor (on)	28.1 (12.6)	26.9 (12.7)	28.9 (12.7)	0.64
FSS	4.2 (0.8)	3.1 (0.6)	5.1 (0.8)	<0.0001
MMSE	27.8 (2.4)	28.2 (1.9)	27.2 (3.0)	0.25
BDI	9.2 (7.2)	7.4 (6.6)	12.0 (7.4)	0.07
BAI	12.2 (8.2)	8.0 (5.2)	15.9 (8.6)	0.001
Apathy Scale	13.2 (6.6)	11.7 (7.1)	14.4 (6.1)	0.20
PDQ 39	28.7 (13.9)	23.8 (12.0)	33.0 (14.2)	0.02

Wilcoxon test was used except for: *Chi Square test was used and **Fisher’s Exact Test was used.
BAI: Beck Anxiety Inventory; BDI: Beck Depression Inventory; DBS: deep brain stimulation; FSS: Fatigue Severity Scale; GPI: globus pallidus interna; MMSE: Mini Mental State Examination; PDQ: Parkinson’s Disease Questionnaire; STN: subthalamic nucleus; UPDRS: Unified Parkinson’s Disease Rating Scale; VIM: ventral intermediate nucleus of thalamus.