Clinical Utility of Skin Biopsy in Differentiating between Parkinson’s Disease and Multiple System Atrophy

<div>Phosphorylated <i>α</i>-synuclein accumulation in the skin nerve fiber. Confocal microscopic colocalization study of phosphorylated <i>α</i>-synuclein deposits (red) in skin biopsied from the lower limb of a patient with Parkinson’s disease. The pan-axonal marker PGP-9.5 in green reveals nerve fibers (arrow) and fibroblasts (arrowheads). Colocalization (yellow) is observed in a subcutaneous nerve fiber. Bar = 10 <i>μ</i>m.</div>

Parkinson’s Disease

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Figure 1

Figure 1: Clinical Utility of Skin Biopsy in Differentiating between Parkinson’s Disease and Multiple System Atrophy 