Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study

Table 2

Discriminant indices of MMSE, MoCA, and NINDS-CSN 5-minute protocol cut-off points in discriminating patients with CDR ≥ 0.5 from those with CDR = 0.

MMSE						MoCA						NINDS-CSN 5-minute protocol
Cut-off	SEN	SPEC	PPV	NPV	Classified	Cut-off	SEN	SPEC	PPV	NPV	Classified	Cut-off	SEN	SPEC	PPV	NPV	Classified
25/26	0.68	0.68	0.76	0.60	0.68	23/24	0.92	0.54	0.74	0.81	0.76	10/11	0.93	0.39	0.69	0.80	0.71
24/25	0.58	0.78	0.80	0.56	0.66	22/23	0.87	0.63	0.78	0.76	0.77	9/10	0.82	0.61	0.75	0.69	0.73
23/24	0.52	0.88	0.86	0.55	0.66	21/22	0.85	0.88	0.91	0.80	0.86	8/9	0.77	0.78	0.84	0.70	0.77
22/23	0.42	0.93	0.89	0.52	0.62	20/21	0.73	0.95	0.96	0.71	0.82	7/8	0.68	0.93	0.93	0.67	0.78
21/22	0.38	1.00	1.00	0.53	0.63	19/20	0.68	0.95	0.95	0.67	0.79	6/7	0.53	1.00	1.00	0.59	0.72

Note: MMSE = Mini Mental State Examination; MoCA = Montreal Cognitive Assessment; NINDS-CSN = National Institute of Neurological Disease and Stroke-Canadian Stroke Network; CDR = Clinical Dementia Rating; SEN = sensitivity; SPEC = specificity; PPV = positive predicted value; NPV = negative predicted value.
Optimal cut-off score.