The Natural History of Depression in Parkinson’s Disease within 30-Month Follow-Up
Table 4
Clinical and demographic correlates of having depression after 30-month follow-up.
Univariate logistic regression
Multivariate logistic regression
SE
Wald
SE
Wald
Sex
−0.683
0.425
2.581
0.108
Age
−0.017
0.023
0.538
0.463
Age at PD onset
−0.001
0.021
0.001
0.976
Education, years
−0.094
0.054
3.059
0.08
Course, years
−0.108
0.066
2.653
0.103
PD types (3 types)
0.051
0.225
0.052
0.819
Levodopa dose at baseline, mg
0.000
0.001
0.096
0.757
Dopamine agonist (yes/no)
−0.02
0.476
0.002
0.967
Antidepressant (yes/no)
0.336
0.683
0.243
0.622
History of depression (yes/no)
−0.947
1.116
0.720
0.396
MMSE baseline
0.021
0.089
0.055
0.815
MMSE change
−0.223
0.077
8.338
0.004
−0.357
0.110
10.47
0.001
UPDRS-II baseline
0.093
0.041
5.139
0.023
0.017
0.069
0.064
0.801
UPDRS-II change
0.033
0.038
0.728
0.393
UPDRS-III baseline
0.040
0.018
4.621
0.032
0.020
0.037
0.298
0.585
UPDRS-III change
0.007
0.013
0.314
0.575
HDRS baseline
0.109
0.036
9.365
0.002
0.156
0.053
8.753
0.003
First univariate logistic regression was used in every variation, respectively, and then we selected those into a multivariate logistic regression equation. Depression was defined as HDRS ≥ 14 at follow-up. was considered significant. Abbreviations: PD: Parkinson’s disease; HDRS: Hamilton Depression Rating Scale; MMSE: Mini-Mental State Examination; UPDRS-II: The Unified Parkinson Disease Rating Scale for motor; UPDRS-III: The Unified Parkinson Disease Rating Scale for Activities of Daily Living portions.
