The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson’s Disease Severity
Table 4
The association of UPDRS scores with UA, serum vitamin D3, and their interaction in total sample as well as in age and sex groups1.
Model 1
value
Model 2
value
Model 3
value
(SE)
(SE)
(SE)
Total samples
UA (mg/dL)
0.027 (0.03)
0.31
0.03 (0.03)
0.31
0.01 (0.03)
0.65
Serum vitamin D3 (ng/mL)
0.27 (0.14)
0.06
0.27 (0.14)
0.05
0.18 (0.14)
0.22
UA & D3
−0.005 (0.004)
0.27
−0.01 (0.01)
0.28
−0.003 (0.01)
0.49
Sexa
Male
UA (mg/dL)
0.05 (0.04)
0.18
0.44 (0.24)
0.03
0.04 (0.04)
0.24
Serum vitamin D3 (ng/mL)
0.44 (0.20)
0.03
0.05 (0.21)
0.18
0.38 (0.21)
0.06
UA & D3
−0.01 (0.01)
0.48
0.01 (0.01)
0.48
−0.008 (0.01)
0.19
Female
UA
0.004 (0.04)
0.93
0.08 (0.04)
0.71
−0.032 (0.03)
0.41
Serum vitamin D3 (ng/mL)
0.08 (0.20)
0.71
0.004 (0.20)
0.93
−0.07 (0.21)
0.77
UA & D3
−0.001 (0.01)
0.90
0.001 (0.01)
0.90
0.003 (0.01)
0.60
Ageb (year)
≤62
UA (mg/dL)
0.08 (0.040)
0.04
0.08 (0.04)
0.07
0.07 (0.04)
0.09
Serum vitamin D3 (ng/mL)
0.44 (0.18)
0.01
0.38 (0.18)
0.03
0.36 (0.19)
0.06
UA & D3
−0.02 (0.01)
0.04
0.01 (0.01)
0.08
−0.01 (0.01)
0.12
>62
UA (mg/dL)
−0.05 (0.041)
0.27
0.04 (0.04)
0.31
−0.04 (0.04)
0.31
Serum vitamin D3 (ng/mL)
−0.10 (0.25)
0.69
0.07 (0.25)
0.79
−0.07 (0.25)
0.79
UA & D3
0.01 (0.01)
0.43
0.01 (0.01)
0.48
0.005 (0.01)
0.48
All presented values are regression coefficient () and its standard error (SE); (Model 1) no adjustment was done for confounding variables; (Model 2) adjustment was done for age and sex; (Model 3) adjustment was done for age, sex, and diseases duration. aAdjustments were made for age and disease duration in Models 2 and 3; badjustments were made for sex and disease duration in Models 2 and 3. The bold numbers are statistically significant at ; UPDRS: Unified Parkinson’s Disease Rating Scale III; UA: uric acid.
