The Effects of Uric Acid, Serum Vitamin D3, and Their Interaction on Parkinson’s Disease Severity

Table 5

Crude and adjusted odds ratio (OR) and 95% CI for OR of the association of H&Y with UA, serum vitamin D3, and their interaction in total study sample as well as in age and sex groups¹.

	Model 1	Model 2	Model 3
	H&Y	H&Y	H&Y
Total samples
UA (mg/dL)	1.41 (0.81–2.43)	1.3 (0.74–2.29)	1.31 (0.74–2.04)
Serum vitamin D3 (ng/mL)	1.01 (0.91–1.11)	0.99 (0.98–1.12)	0.99 (0.89–1.10)
UA & D3	0.99 (0.98–1.01)	0.99 (0.98–1.02)	0.99 (0.98–1.02)
Sex
Male
UA(mg/dL)	1.83 (0.82–4.06)	1.79 (0.803–4.01)	1.80 (0.79–4.01)
Serum vitamin D3 (ng/mL)	1.04 (0.91–1.20)	1.04 (0.90–1.20)	1.04 (0.90–1.20)
UA & D3	0.994 (0.97–1.02)	0.994 (0.97–1.19)	0.99 (0.97–1.02)
Female
UA (mg/dL)	1.29 (0.55–3.03)	1.08 (0.38–3.03)	0.90 (0.19–4.29)
Serum vitamin D3 (ng/mL)	0.98 (0.82–1.16)	0.91 (0.744–1.12)	0.81 (0.57–1.16)
UA & D3	0.99 (0.97–1.03)	1.00 (0.969–1.04)	1.01 (0.95–1.05)
Age(year)
≤62
UA (mg/dL)	1.90 (0.95–3.80)	1.76 (0.86–3.61)	1.59 (0.75–3.36)
Serum vitamin D3 (ng/mL)	1.13 (0.97–1.32)	1.12 (0.95–1.31)	1.10 (0.94–1.29)
UA & D3	0.98 (0.96–1.01)	0.99 (0.96–1.01)	0.99 (0.96–1.01)
>62
UA (mg/dL)	0.83 (0.32–2.16)	0.87 (0.32–2.39)	0.96 (0.34–2.72)
Serum vitamin D3 (ng/mL)	0.89 (0.76–1.05)	0.89 (0.752–1.05)	0.89 (0.76–1.06)
UA & D3	1.02 (0.99–1.04)	1.02 (0.99–1.04)	1.01 (0.98–1.04)

All presented values are OR (95% CI for OR) which resulted from multivariable logistic regression; (Model 1) no adjustment was done for confounding variables; (Model 2) adjustment was done for age and sex; (Model 3) adjustment was done for age, sex, and diseases duration; H&Y: Hoehn and Yahr.