Deep Brain Stimulation Can Preserve Working Status in Parkinson’s Disease
Table 2
Comparison of “active job” and “no job” groups regarding the achieved improvements in health-related quality of life and major symptoms of Parkinson’s disease after bilateral subthalamic deep brain stimulation.
Active job group (at the time of surgery)
No job group (at the time of surgery)
Between groups (Mann-Whitney)
Median
Percentile 25
Percentile 75
Mean
Standard deviation
Friedman test (within group)
Median
Percentile 25
Percentile 75
Mean
Standard deviation
Friedman test (within group)
EQ-5D
Baseline
0.477
0.116
0.605
0.391
0.307
0.429
0.255
0.666
0.411
0.308
0.779
1 year
0.660
0.530
0.770
0.661
0.163
<0.001
0.507
0.439
0.691
0.543
0.183
<0.001
0.035
2 years
0.687
0.620
0.811
0.710
0.138
0.587
0.482
0.742
0.606
0.191
0.045
EQ-5D VAS
Baseline
70
55
80
68.1
14.0
67
50
79
64.4
17.7
0.495
1 year
84
71
93
80.4
14.9
<0.001
70
60
82
69.4
16.2
<0.001
0.037
2 years
88
77
90
81.2
15.0
73
60
80
71.5
14.9
0.021
SES
Baseline
70
60
80
71.5
11.8
70
65
80
71.0
15.5
0.845
1 year
80
75
90
82.0
11.5
<0.001
80
70
80
76.5
11.8
0.002
0.153
2 years
80
80
90
81.5
11.4
70
59
80
68.9
11.9
0.001
UPDRS-III
Baseline
25
22
29
25.6
6.3
24
19
30
23.9
7.2
0.506
1 year
22
18
26
22.1
5.3
<0.001
22
18
27
22.0
6.3
<0.001
0.839
2 years
22
17
24
20.8
5.0
20
17
26
20.8
6.4
0.860
UPDRS-II
Baseline
15
14
19
15.4
4.7
15
12
19
14.9
5.3
0.724
1 year
13
10
17
12.9
4.3
<0.001
16
10
19
14.8
6.3
<0.001
0.243
2 years
12
9
16
12.2
4.9
15
11
19
15.1
6.9
0.116
MADRS
Baseline
7
6
10
7.9
3.8
8
5
9
7.9
3.2
0.744
1 year
6
5
9
6.8
2.6
0.020
7
5
10
7.4
3.5
0.590
0.395
2 years
5
5
7
5.7
1.6
7
5
10
7.4
3.2
0.066
MDRS
Baseline
135
130
139
134.5
5.6
136
130
143
136.1
6.2
0.342
1 year
134
128
136
133.1
5.8
0.246
133
127
140
133.1
6.2
0.215
0.903
2 years
134
130
137
132.7
6.3
133
127
140
133.2
6.2
0.839
LED
Baseline
905.0
780.0
1060.0
972.9
379.2
950
750
1000
925.0
265.3
0.903
1 year
475.0
325.0
700.0
535.1
315.0
<0.001
509.0
400.0
678.5
559.7
216.6
<0.001
0.447
2 years
500.0
375.0
700.0
552.5
250.5
525.0
406.0
700.0
575.0
186.5
0.463
Friedman test was used to evaluate within-group changes (comparison of baseline values with 1st year and 2nd year of follow-up). Mann-Whitney test was applied to detect between-groups differences (e.g., comparison of “active job” group versus “no job” group). HYS = Hoehn-Yahr Stages; LED = levodopa equivalent dosage; MADRS = Montgomery-Asberg Depression Rating Scale; MDRS = Mattis Dementia Rating Scale; SES = Schwab and England Scale; UPDRS-II = Activities of Daily Living (Part II of UPDRS); UPDRS = Unified Parkinson’s Disease Rating Scale; UPDRS-III = Motor Examination (Part III of UPDRS); EQ-5D = EuroQol Instrument.
