Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson’s Disease

Figure 1

Schematic diagram of the domain architecture of LRRK2. Above, the segregating mutations of LRRK2 in Parkinson’s disease are shown (arrows). ARM: Armadillo repeats, ANK: Ankyrin repeats, LRR: leucine-rich repeats, and WD: WD40 repeats.