Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson’s Disease

Figure 2

Proposed model of the activation mechanism of LRRK2. LRRK2 activation is at least regulated by three different mechanisms: cycling between (1) an almost inactive monomer and active dimer at the membrane, (2) intramolecular activation, and (3) binding of input/substrate to the N- and C-terminal domains.