Hepcidin Plays a Key Role in 6-OHDA Induced Iron Overload and Apoptotic Cell Death in a Cell Culture Model of Parkinson’s Disease

Figure 2

The role of hepcidin knockdown in 6-OHDA induced cytotoxicity measured by MTT ((a), ), caspase-3 activity ((b), -5), and DNA fragmentation ((c), ) in N27 cells. Cells were treated with 100 μM 6-OHDA for 6 hours and the values (mean ± SEM) are normalized to their respective controls without 6-OHDA treatment; ; difference between two groups was based on Student’s -test; control siRNA: scrambled small interfering RNA; hepcidin siRNA: hepcidin small interfering RNA.

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