Parkinson’s Disease / 2016 / Article / Tab 4 / Research Article
Using Tractography to Distinguish SWEDD from Parkinson’s Disease Patients Based on Connectivity Table 4 Correlation with clinical scores was investigated. Structural connectivity values based on the number of fibers connecting two regions are reported within the identified connections. Correlations between structural connectivity and MDS-UPDSR score are reported as Spearman correlation coefficients, with corrected
values in the rightmost column. Bold text shows the connections that significantly correlated with MDS-UPDRS-III (corrected
).
Correlation with MDS-UPDRS-III score Connection Number of fibers (mean ± SD) Corr coef. (corrected PD SWEDD Total (a) Cortico-cortical connection L_precentral-L_posteriorcingulate 4.6 ± 8.23 1.56 ± 2.89 3.14 ± 6.39 0.16 (1) L_paracentral-L_superiorfrontal 1.18 ± 1.67 3.21 ± 6.29 2.15 ± 4.61 −0.32 (<0.001) L_paracentral-L_posteriorcingulate 8.72 ± 8.32 3.48 ± 4.35 6.21 ± 7.17 0.15 (1) L_posteriorcingulate-L_superiorfrontal 11.7 ± 8.96 6.27 ± 6.23 9.09 ± 8.20 0.04 (1) L_parsorbitalis-R_superiorfrontal 0.65 ± 3.33 2.18 ± 4.72 1.39 ± 4.10 0.01 (1) R_paracentral-L_paracentral 0.65 ± 2.02 2.59 ± 4.5 1.58 ± 5.56 0.03 (1) R_paracentral-R_posteriorcingulate 37.7 ± 23.47 17.8 ± 23.3 28.19 ± 25.33 0.56 (<0.001) R_precentral-R_posteriorcingulate 13.1 ± 16.75 5.54 ± 14.3 9.47 ± 15.98 0.17 (0.992) R_posteriorcingulate-R_superiorfrontal 43.67 ± 27.54 19.94 ± 21.7 32.27 ± 27.48 0.54 (<0.001) R_posteriorcingulate-R_superiorparietal 10.45 ± 17.27 3.00 ± 6.78 6.87 ± 13.74 0.27 (0.057) R_rostralmiddlefrontal-R_inferiorparietal 1.42 ± 3.20 0.29 ± 1.17 0.88 ± 2.50 0.03 (1) (b) Cortico-subcortical connection L_pallidum-L_frontalpole 0.77 ± 1.51 2.83 ± 6.40 1.76 ± 4.65 −0.04 (1) L_pallidum-L_postcentral 5.52 ± 9.17 16.08 ± 26.3 10.60 ± 19.98 0.18 (0.85) L_putamen-L_precentral 14.5 ± 8.95 24.86 ± 24.48 19.48 ± 18.77 0.54 (<0.001) L_putamen-L_rostralmiddlefrontal 34.87 ± 30.86 21.83 ± 21.34 28.61 ± 27.34 0.09 (1) L_caudate-L_rostralmiddlefrontal 37.5 ± 41.4 15.59 ± 24.66 26.97 ± 35.90 −0.08 (1) L_thalamusproper-L_rostralmiddlefrontal 7.27 ± 9.75 3.27 ± 5.02 5.35 ± 8.05 0.02 (1) R_pallidum-R_superiorfrontal 1.50 ± 2.76 4.57 ± 7.97 2.97 ± 6.03 0.01 (1) (c) Subcortical connection L_caudate-L_putamen 2.28 ± 3.34 5.59 ± 7.58 3.7 ± 5.98 0.06 (1) R_putamen-R_pallidum 2.28 ± 2.33 4.51 ± 3.98 3.35 ± 3.40 −0.14 (1) Brainstem-L_putamen 3.80 ± 5.71 7.78 ± 10.96 5.71 ± 8.81 0.15 (1) Brainstem-L_caudate 2.00 ± 4.29 4.51 ± 6.46 3.21 ± 5.55 0.01 (1) Brainstem-R_thalamusproper 31.48 ± 18.72 42.08 ± 23.13 36.57 ± 21.49 0.19 (0.648)
