Preoperative Attention/Memory Problem Affects the Quality of Life of Parkinson’s Disease Patients after Deep Brain Stimulation: A Cohort Study
Table 2
Outcome parameters assessed at preoperative baseline and at postoperative 6- and 12-month follow-ups for a total of 93 participants (N = 93).
Variable
Baseline
6-month follow-up
12-month follow-up
Post hoc tests
Mean
SD
Mean
SD
Mean
SD
PDQ-8 summary index
12.42
6.04
3.92
4.04
3.03
3.86
<0.001
a b c
NMSS domains
Cardiovascular
1.39
2.67
0.67
1.86
0.69
1.91
0.075
—
Sleep/fatigue
15.12
11.95
5.77
7.27
5.67
6.03
<0.001
a b c
Mood/cognition
11.27
14.57
5.86
10.62
5.70
9.73
0.006
a b c
Perceptual problems/hallucinations
1.47
3.47
0.47
1.96
0.43
1.68
0.030
a b c
Attention/memory
5.43
7.23
2.77
3.94
1.91
3.43
<0.001
a b c
Gastrointestinal
7.87
8.04
5.89
5.86
6.63
6.58
0.163
—
Urinary
7.23
9.17
2.10
5.93
0.85
2.79
<0.001
a b c
Sexual function
1.51
4.06
0.18
0.99
0.18
1.17
0.010
a b c
Miscellaneous
9.63
10.14
4.08
5.66
5.19
6.88
<0.001
a b c
NMSS total score
60.91
47.98
27.80
26.68
27.26
25.32
<0.001
a b c
Post hoc comparisons (Tamhane’s T2 test): a = significant difference between baseline and 6-month follow-up (); b = significant difference between baseline and 12-month follow-up (); c = significant difference between 6-month follow-up and 12-month follow-up (). indicates , indicates , indicates .
