Transfection of the BDNF Gene in the Surviving Dopamine Neurons in Conjunction with Continuous Administration of Pramipexole Restores Normal Motor Behavior in a Bilateral Rat Model of Parkinson’s Disease

Figure 1

Experimental protocol. 6-OHDA was injected into three sites in the right striatum and one week later into the contralateral striatum (see Methods and Materials for coordinates). PPX was continuously infused via subcutaneously implanted osmotic pumps. The BDNF gene was transfected once one month after the start of the PPX infusion. The final rotarod and beam test was performed two and a half months after the end of the PPX infusion.