Transfection of the BDNF Gene in the Surviving Dopamine Neurons in Conjunction with Continuous Administration of Pramipexole Restores Normal Motor Behavior in a Bilateral Rat Model of Parkinson’s Disease

<div>Colocalization of TH+/BDNF-flag in dopamine neurons of the substantia nigra and ventral tegmental area. Representative micrographs (a, b). Immunohistochemistry was performed 36 weeks after the lesion and two and a half months after the end of treatment. The histograms (c) show the percentage of BDNF-flag expression in TH (+) neurons of the substantia nigra <i>pars compacta</i> and the ventral tegmental area. <i>n</i> = 7.</div>

Parkinson’s Disease

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Figure 7

Figure 7: Transfection of the BDNF Gene in the Surviving Dopamine Neurons in Conjunction with Continuous Administration of Pramipexole Restores Normal Motor Behavior in a Bilateral Rat Model of Parkinson’s Disease 

Figure 7 | Transfection of the BDNF Gene in the Surviving Dopamine Neurons in Conjunction with Continuous Administration of Pramipexole Restores Normal Motor Behavior in a Bilateral Rat Model of Parkinson’s Disease 