A Systematic Review and Meta-Analysis of the Efficacy and Safety of Rasagiline or Pramipexole in the Treatment of Early Parkinson’s Disease

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Outcome</td><td class="align_center">Treatment</td><td class="align_center">Number of studies</td><td class="align_center">Quality of the evidence (GRADE)</td><td class="align_center">Conclusion</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left" rowspan="2">Change in UPDRS II</td><td class="align_center">Rasagiline</td><td class="align_center">5 (5)</td><td class="align_center">Moderate</td><td class="align_center" rowspan="4">Possible benefit; however, additional research is needed</td></tr><tr><td class="align_center">Pramipexole</td><td class="align_center">7 (5)</td><td class="align_center">Moderate</td></tr><tr><td class="align_left" rowspan="2">Change in UPDRS III</td><td class="align_center">Rasagiline</td><td class="align_center">5 (5)</td><td class="align_center">Moderate</td></tr><tr><td class="align_center">Pramipexole</td><td class="align_center">7 (5)</td><td class="align_center">Moderate</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>Values in parentheses represent the number of studies that contributed to the meta-analyses. UPDRS = the unified Parkinson's Disease rating scale. GRADE = grading of recommendations, assessment, development, and evaluations.<br/></div></td></tr></table>

Parkinson’s Disease

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Table 5

Table 5: A Systematic Review and Meta-Analysis of the Efficacy and Safety of Rasagiline or Pramipexole in the Treatment of Early Parkinson’s Disease 