Factors Influencing Oxidative Imbalance in Pulmonary Fibrosis: An Immunohistochemical Study
Figure 3
Expression of signal transduction mediators in UIP (a, c, e) and in COP (b, d, f). In both lesions, NF-κB expression is only observed in infiltrating lymphocytes (a, b), while phosphorylated SMAD2 is present in a large number of epithelial, inflammatory and mesenchymal cells (c, d). SMAD3 is expressed in the nuclei of epithelial cells overlying FF in UIP (e), while diffuse cytoplasmic stain characterizes COP fibroblast plugs (f).
