Factors Influencing Oxidative Imbalance in Pulmonary Fibrosis: An Immunohistochemical Study
Figure 5
Comparison between organizing pneumonia fibroblast plugs (a, c) and UIP FF (b, d). Higher i-NOS expression is present in COP (a) than in UIP (b), mostly due to endothelial and inflammatory cell stain, but also to fibroblast expression, Epithelial cells in FF are more reactive than in COP. Nitrotyrosine reactivity is diffuse and intense in all COP cellular components (c). In UIP FF (d) nitrotyrosine expression is limited to epithelial cells and inflammatory aggregates (upper right corner), while stromal cells are completely negative.
