Rapamycin Regulates Bleomycin-Induced Lung Damage in SP-C-Deficient Mice
Figure 1
Early rapamycin treatment does not reduce bleomycin-induced acute lung injury in or −/− mice. (a) Diagram of experimental protocol for prevention study to test affects of rapamycin on bleomycin-induced lung fibrosis. and −/− mice were treated with daily rapamycin or vehicle 2 days prior to administration of intratracheal bleomycin or saline. (b) Changes in body weights, total BALF cells, BALF protein, and total lung collagen are shown fro mice. (c) Changes in body weights, total BALF cells, BALF protein, and total lung collagen are shown for mice. (d) H&E stained representative lung histology is shown, all panels 40x magnification.
