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Pulmonary Medicine
Volume 2012 (2012), Article ID 249082, 8 pages
http://dx.doi.org/10.1155/2012/249082
Review Article

Ancillary Testing in Lung Cancer Diagnosis

1Department of Pathology, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, ON, Canada M5G 2C4
2Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada M5S 1A8
3Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, ON, Canada M5G 2M9

Received 15 July 2011; Accepted 5 October 2011

Academic Editor: Joanna Domagala-Kulawik

Copyright © 2012 William Dubinski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. D. Travis, E. Brambilla, H. K. Muller-Hermelink, and C. C. Harris, Pathology and Genetics of Tumours of the Lung, Pleura, Thymus, and Heart, World Health Organization Classification of Tumours, IARC, Lyon, France, 2004.
  2. W. D. Travis, E. Brambilla, M. Noguchi et al., “International association for the study of lung cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma,” Journal of Thoracic Oncology, vol. 6, no. 2, pp. 244–285, 2011. View at Publisher · View at Google Scholar
  3. B. Xu, N. Thong, D. Tan, and T. Khoury, “Expression of thyroid transcription factor-1 in colorectal carcinoma,” Applied Immunohistochemistry and Molecular Morphology, vol. 18, no. 3, pp. 244–249, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. P. S. Loo, S. C. Thomas, M. C. Nicolson, M. N. Fyfe, and K. M. Kerr, “Subtyping of undifferentiated non-small cell carcinomas in bronchial biopsy specimens,” Journal of Thoracic Oncology, vol. 5, no. 4, pp. 442–447, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. A. G. Nicholson, D. Gonzalez, P. Shah et al., “Refining the diagnosis and EGFR status of non-small cell lung carcinoma in biopsy and cytologic material, using a panel of Mucin staining, TTF-1, cytokeratin 5/6, and P63, and EGFR mutation analysis,” Journal of Thoracic Oncology, vol. 5, no. 4, pp. 436–441, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Ye, J. J. Findeis-Hosey, Q. Yang et al., “Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung,” Applied Immunohistochemistry and Molecular Morphology, vol. 19, no. 4, pp. 313–317, 2011. View at Publisher · View at Google Scholar
  7. V. Monica, P. Ceppi, L. Righi et al., “Desmocollin-3: a new marker of squamous differentiation in undifferentiated large-cell carcinoma of the lung,” Modern Pathology, vol. 22, no. 5, pp. 709–717, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Schweizer, P. E. Bowden, P. A. Coulombe et al., “New consensus nomenclature for mammalian keratins,” Journal of Cell Biology, vol. 174, no. 2, pp. 169–174, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. V. Boggaram, “Thyroid transcription factor-I (TTF-I/Nkx2.I/TITFI) gene regulation in the lung,” Clinical Science, vol. 116, no. 1, pp. 27–35, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. D. H. Johnson, L. Fehrenbacher, W. F. Novotny et al., “Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer,” Journal of Clinical Oncology, vol. 22, no. 11, pp. 2184–2191, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. A. B. Sandler, J. H. Schiller, R. Gray et al., “Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with carboplatin and paclitaxel plus bevacizumab,” Journal of Clinical Oncology, vol. 27, no. 9, pp. 1405–1412, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. M. A. Socinski, S. Novello, J. R. Brahmer et al., “Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer,” Journal of Clinical Oncology, vol. 26, no. 4, pp. 650–656, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. G. V. Scagliotti, P. Parikh, J. Von Pawel et al., “Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer,” Journal of Clinical Oncology, vol. 26, no. 21, pp. 3543–3551, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Ciuleanu, T. Brodowicz, C. Zielinski et al., “Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study,” The Lancet, vol. 374, no. 9699, pp. 1432–1440, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Yatabe, T. Mitsudomi, and T. Takahashi, “TTF-1 expression in pulmonary adenocarcinomas,” American Journal of Surgical Pathology, vol. 26, no. 6, pp. 767–773, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Fatima, C. Cohen, D. Lawson, and M. T. Siddiqui, “TTF-1 and Napsin A double stain: a useful marker for diagnosing lung adenocarcinoma on fine-needle aspiration cell blocks,” Cancer Cytopathology, vol. 119, no. 2, pp. 127–133, 2011. View at Publisher · View at Google Scholar
  17. E. Lim, P. Goldstraw, A. G. Nicholson et al., “Proceedings of the IASLC international workshop on advances in pulmonary neuroendocrine tumors 2007,” Journal of Thoracic Oncology, vol. 3, no. 10, pp. 1194–1201, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Rekhtman, “Neuroendocrine tumors of the lung: an update,” Archives of Pathology and Laboratory Medicine, vol. 134, no. 11, pp. 1628–1638, 2010. View at Scopus
  19. D. L. Asian, H. E. Gulbahce, S. E. Pambuccian, J. C. Manivel, and J. Jessurun, “Ki-67 immunoreactivity in the differential diagnosis of pulmonary neuroendocrine neoplasms in specimens with extensive crush artifact,” American Journal of Clinical Pathology, vol. 123, no. 6, pp. 874–878, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Z. Du, P. Goldstraw, J. Zacharias et al., “TTF-1 expression is specific for lung primary in typical and atypical carcinoids: TTF-1-positive carcinoids are predominantly in peripheral location,” Human Pathology, vol. 35, no. 7, pp. 825–831, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. O. Kaufmann and M. Dietel, “Expression of thyroid transcription factor-1 in pulmonary and extrapulmonary small cell carcinomas and other neuroendocrine carcinomas of various primary sites,” Histopathology, vol. 36, no. 5, pp. 415–420, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. W. S. El-Deiry, “Review: the p53 pathway and cancer therapy,” The Cancer Journal, vol. 11, pp. 229–236, 1998.
  23. M. S. Tsao, S. Aviel-Ronen, K. Ding et al., “Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non-small-cell lung cancer,” Journal of Clinical Oncology, vol. 25, no. 33, pp. 5240–5247, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Miki, D. W. Ball, and R. I. Linnoila, “Insights into the achaete-scute homolog-1 gene (hASH1) in normal and neoplastic human lung,” Lung Cancer, vol. 75, no. 1, pp. 58–65, 2012. View at Publisher · View at Google Scholar
  25. L. E. Coate, T. John, M. S. Tsao, and F. A. Shepherd, “Molecular predictive and prognostic markers in non-small-cell lung cancer,” The Lancet Oncology, vol. 10, no. 10, pp. 1001–1010, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. F. R. Hirsch, M. Varella-Garcia, P. A. Bunn Jr. et al., “Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis,” Journal of Clinical Oncology, vol. 21, no. 20, pp. 3798–3807, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Rosell, T. Moran, C. Queralt et al., “Screening for epidermal growth factor receptor mutations in lung cancer,” New England Journal of Medicine, vol. 361, no. 10, pp. 958–967, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. T. S. Mok, Y. L. Wu, S. Thongprasert et al., “Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma,” New England Journal of Medicine, vol. 361, no. 10, pp. 947–957, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. P. A. Bunn, R. Dziadziuszko, M. Varella-Garcia et al., “Biological markers for non-small cell lung cancer patient selection for epidermal growth factor receptor tyrosine kinase inhibitor therapy,” Clinical Cancer Research, vol. 12, no. 12, pp. 3652–3656, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. D. M. Jackman, V. A. Miller, L. A. Cioffredi et al., “Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: results of an online tumor registry of clinical trials,” Clinical Cancer Research, vol. 15, no. 16, pp. 5267–5273, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. G. J. Riely, K. A. Politi, V. A. Miller, and W. Pao, “Update on epidermal growth factor receptor mutations in non-small cell lung cancer,” Clinical Cancer Research, vol. 12, no. 24, pp. 7232–7241, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. T. John, G. Liu, and M. S. Tsao, “Overview of molecular testing in non-small-cell lung cancer: mutational analysis, gene copy number, protein expression and other biomarkers of EGFR for the prediction of response to tyrosine kinase inhibitors,” Oncogene, vol. 28, supplement 1, pp. S14–S23, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. H. Shigematsu, L. Lin, T. Takahashi et al., “Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers,” Journal of the National Cancer Institute, vol. 97, no. 5, pp. 339–346, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Yu, S. Kane, J. Wu et al., “Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer,” Clinical Cancer Research, vol. 15, no. 9, pp. 3023–3028, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. S. A. Ahrendt, P. Anthony Decker, E. A. Alawi et al., “Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung,” Cancer, vol. 92, no. 6, pp. 1525–1530, 2001. View at Scopus
  36. C. Mascaux, N. Iannino, B. Martin et al., “The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis,” British Journal of Cancer, vol. 92, no. 1, pp. 131–139, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. K. Suda, K. Tomizawa, and T. Mitsudomi, “Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation,” Cancer and Metastasis Reviews, vol. 29, no. 1, pp. 49–60, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. D. M. Jackman, V. A. Miller, L. A. Cioffredi et al., “Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: results of an online tumor registry of clinical trials,” Clinical Cancer Research, vol. 15, no. 16, pp. 5267–5273, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Sakurada and M. S. Tsao, “Predictive biomarkers for EGFR therapy,” IDrugs, vol. 12, no. 1, pp. 34–38, 2009. View at Scopus
  40. Y. P. Mossé, A. Wood, and J. M. Maris, “Inhibition of ALK signaling for cancer therapy,” Clinical Cancer Research, vol. 15, no. 18, pp. 5609–5614, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Soda, Y. L. Choi, M. Enomoto et al., “Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer,” Nature, vol. 448, no. 7153, pp. 561–566, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Soda, S. Takada, K. Takeuchi et al., “A mouse model for EML4-ALK-positive lung cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 50, pp. 19893–19897, 2008. View at Publisher · View at Google Scholar · View at Scopus
  43. E. L. Kwak, Y. J. Bang, D. R. Camidge et al., “Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer,” New England Journal of Medicine, vol. 363, no. 18, pp. 1693–1703, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. B. Solomon, M. Varella-Garcia, and D. R. Camidge, “ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer,” Journal of Thoracic Oncology, vol. 4, no. 12, pp. 1450–1454, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. S. J. Rodig, M. Mino-Kenudson, S. Dacic et al., “Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population,” Clinical Cancer Research, vol. 15, no. 16, pp. 5216–5223, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. A. T. Shaw, B. Y. Yeap, M. Mino-Kenudson et al., “Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK,” Journal of Clinical Oncology, vol. 27, no. 26, pp. 4247–4253, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. T. Sasaki, S. J. Rodig, L. R. Chirieac, and P. A. Jänne, “The biology and treatment of EML4-ALK non-small cell lung cancer,” European Journal of Cancer, vol. 46, no. 10, pp. 1773–1780, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. M. Mino-Kenudson, L. R. Chirieac, K. Law et al., “A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry,” Clinical Cancer Research, vol. 16, no. 5, pp. 1561–1571, 2010. View at Publisher · View at Google Scholar · View at Scopus
  49. W. A. Cooper, S. O'toole, M. Boyer, L. Horvath, and A. Mahar, “What's new in non-small cell lung cancer forpathologists: the importance of accurate subtyping, EGFR mutations and ALK rearrangements,” Pathology, vol. 43, no. 2, pp. 103–115, 2011. View at Publisher · View at Google Scholar
  50. J. G. Christensen, J. Burrows, and R. Salgia, “c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention,” Cancer Letters, vol. 225, no. 1, pp. 1–26, 2005. View at Publisher · View at Google Scholar · View at Scopus
  51. E. S. Kim and R. Salgia, “MET pathway as a therapeutic target,” Journal of Thoracic Oncology, vol. 4, no. 4, pp. 444–447, 2009. View at Publisher · View at Google Scholar · View at Scopus
  52. F. Cappuzzo, A. Marchetti, M. Skokan et al., “Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients,” Journal of Clinical Oncology, vol. 27, no. 10, pp. 1667–1674, 2009. View at Publisher · View at Google Scholar · View at Scopus
  53. J. A. Engelman, K. Zejnullahu, T. Mitsudomi et al., “MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling,” Science, vol. 316, no. 5827, pp. 1039–1043, 2007. View at Publisher · View at Google Scholar · View at Scopus
  54. L. V. Sequist, B. A. Waltman, D. Dias-Santagata et al., “Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors,” Science Translational Medicine, vol. 3, no. 75, 2011. View at Publisher · View at Google Scholar
  55. H. Kadara, C. Behrens, P. Yuan et al., “A five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis,” Clinical Cancer Research, vol. 17, no. 6, pp. 1490–1501, 2011. View at Publisher · View at Google Scholar
  56. H. Y. Chen, S. L. Yu, C. H. Chen et al., “A five-gene signature and clinical outcome in non-small-cell lung cancer,” New England Journal of Medicine, vol. 356, no. 1, pp. 11–20, 2007. View at Scopus