Table 3: Clinically relevant molecular and clinicopathologic features of NSCLC.

EGFR mutationK-ras mutationEML4-ALK mutation

Histologic subtypeAdenocarcinomaNSCLC (Adeno > squamous)Adenocarcinoma, signet ring morphology
Clinical featuresAsian, female, light/never smokersPast or present smokersLight/never smokers, possible young age and male
SignificanceSensitive to EGFR TKI therapyRelative resistance to EGFR TKI therapy, possible poor prognostic markerUse of ALK inhibitors (currently under study)