The Immune Response and Its Therapeutic Modulation in Bronchiectasis

Table 1

Proinflammatory and immune mediators upregulated during bronchiectasis.

Class of mediators	Type of mediators
Cytokines	TNFα, IL-1α, IL-1β, IL-6, IL-8, TGFβ
Proteases	Neutrophil elastase, MMP2, MMP8, MMP9, MMP-13, Cathepsin B, Cathepsin G, mast cell tryptase
Leukotrienes (LT)	LTB4
Adhesion molecules	ICAM-1, E-selectin, VCAM-1
Granule proteins	Myeloperoxidase
Acute-phase proteins	C-reactive protein (CRP), serum amyloid A (SAA)
Free radicals (exhaled)	NO, H2O2