Review Article

The Relationship between Obstructive Sleep Apnea and Atrial Fibrillation: A Complex Interplay

Table 1

Risk of AF in OSA patients.

InvestigatorNumber of patientsMethods of diagnosis for OSAControl groupRisk factor adjustmentsResults

Guilleminault et al. (1983) [6]400PSGNoN/ACardiac arrhythmias observed in 48% of patients with OSA
Mooe et al. (1996) [14]121 PSGYesAge.Risk of AF after CABG in OSA patients, OR 2.8 (1.2–6.8)
Mehra et al. (2006) [8]566PSGYesAge, gender, BMI, coronary heart disease.Risk of AF in OSA patients, adjusted OR 4.02 (1.03–15.74)
Tanigawa et al. (2006) [9]1763 Pulse oximeter during sleepYesAge, BMI, alcohol intake, blood pressure, hypertension, and antihypertensives.Risk of AF for severe OSA, adjusted OR 5.66 (1.75–18.34)
Gami et al. (2007) [11]3542 PSGYesAge, gender, coronary artery disease, BMI.Incident AF in OSA for patients age <65, HR 3.29 (1.35–8.04)
Monahan et al. (2009) [10]2816 PSGYesSubjects serve as their own controls during event-free periods.Risk of AF after a respiratory disturbance compared to normal breathing, OR 17.9 (2.2–144.2)
Mehra et al. (2009) [15]2911PSGYesAge, race, BMI, HTN, DM, CAD, pacemaker, cholesterol.Increasing OSA quartile associated with CVE ( ) but not AF.

PSG: polysomnogram; CABG: coronary artery bypass graft; BMI: body mass index; HTN: hypertension; DM: diabetes mellitus; CAD: cardiac disease; OR: odds ratio; HR: hazard ratio; CVE: complex ventricular ectopy.