| | Investigator | Number of patients | Primary endpoints | Mean followup (yrs) | Control for AF | Risk factor adjustments | Results for stroke |
| | Boden-Albala et al. (2012) [92] | 2088 | Ischemic stroke, MI, death | 5.1 | Yes | Age, sex, race, education, WC, systolic and diastolic BP, fasting glucose, HDL, alcohol, smoking, physical activity, PVD, CAD, total cholesterol/HDL level, depression, and medication usage. | HR for ischemic stroke in patients with significant dozing was 2.74 (1.38–5.43); HR for all stroke, 3.00 (1.57–5.73) | | Redline et al. (2010) [93] | 5422 | Ischemic stroke | 8.7 | No | Age, race, BMI, smoking, BP, antihypertensives, DM. | Adjusted HR for stroke in men with severe OSA was 2.86 (1.10–7.39) | | Munoz et al. (2006) [94] | 394 | Stroke | 4.5 | Yes | Sex. | Adjusted HR for stroke in OSA patients was 2.52 (1.04–6.10) | | Yaggi et al. (2005) [95] | 1022 | Stroke or death | 3.4 | Yes | Age, race, sex, smoking, alcohol consumption, BMI, AF, HTN, and lipids. | Unadjusted RR for stroke in OSA was 3.02 (1.27–7.21), death adjusted RR, 1.70 (0.92–3.16) | | Arzt et al. (2005) [45] | 1189 | Stroke | 4 | No | Age, sex, and BMI. | Fully adjusted OR for stroke in severe OSA was 3.08 (0.74–12.81) | | Marin et al. (2005) [96] | 1010 | Fatal MI, stroke | 10.1 | No | Age, CV disease, DM, HTN, lipid disorders, smoking, alcohol use, BP, glucose, lipid levels, and CV drugs. | OR for fatal MI or stroke in untreated severe OSA was 2.87 (1.17–7.51) | | Mooe et al. (2001) [97] | 408 | Death, cerebrovascular events, MI | 5.1 | No | Age, sex, BMI, HTN, DM, left ventricular function, and coronary intervention. | OR for stroke in moderate OSA patients was 2.62 (1.26–5.46), in severe OSA patients, 2.98 (1.43–6.20) | Hu et al. (2000)
[98] | 71,779 women | Stroke, coronary heart disease, fatal cardiovascular events | 8 | No | Age, BMI, cigarette smoking, DM, hypercholesterolemia, menopausal status, family history of MI before age 60, alcohol consumption, multivitamin and vitamin E use, physical activity, number of hours sleeping, and sleep position. | Age-adjusted total stroke RR for occasional snorers, 1.60 (1.21–2.12); for regular snorers 1.88 (1.29–2.74).
Multivariate adjusted RR for occasional snorers, 1.42 (1.07–1.89); for regular snorers RR 1.35 (0.91–1.99) |
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