Practical Guidelines: Lung Transplantation in Patients with Cystic Fibrosis

Table 2

Contraindications to LTX.

(a) Absolute contraindications to LTX

(i) Malignant diseases in the past 2 years
(ii) Untreatable severe dysfunction of another important organ system (heart, liver, and kidney) not amenable to surgical correction/combined TX
(iii) Chronic, incurable extrapulmonary infection
(iv) Severe deformations of chest and spine
(v) Severe or symptomatic osteoporosis
(vi) Lack of adherence to therapy
(vii) Untreatable mental disorders combined with lack of cooperation
(viii) Addictive disorder currently or during the past 6 months (tobacco and alcohol addiction, substance abuse)

(b) Relative contraindications to LTX

(i) Age > 65 years
(ii) Critical/unstable clinical situation
(iii) Seriously limited functional status without potential for rehabilitation
(iv) Colonisation with Burkholderia cenocepacia, Burkholderia gladioli and Mycobacteria abscessus
(v) Diseases not optimally treated (e.g., arterial hypertension, diabetes mellitus, GERD, osteoporosis, and coronary heart disease)