Pulmonary Medicine / 2014 / Article / Tab 2 / Review Article
Biomarkers to Improve Diagnosis and Monitoring of Obstructive Sleep Apnea Syndrome: Current Status and Future Perspectives Table 2 Effects of continuous positive airway pressure treatment on several biomarkers in obstructive sleep apnea syndrome.
Study Biomarkers CPAP treatment duration Comments Yokoe et al. [26 ] CRP 1 month CRP, IL-6 levels, and spontaneous IL-6 production by monocytes were significantly decreased after treatment Steiropoulos et al. [27 ] CRP 6 months CRP levels were decreased in the group with good adherence to treatment Kohler et al. [28 ] CRP 1 month CRP and IL-6 levels were not decreased after treatment Minoguchi et al. [36 ] TNF-α 1 month Serum levels and spontaneous production of TNF-α were decreased in patients with moderate-to-severe OSAS Steiropoulos et al. [41 ] TNF-α 6 months TNF-α levels were decreased in the good compliance group after treatment. IL-6 levels did not alter with treatment Hegglin et al. [42 ] TNF-α 8 months TNF-α levels were decreased in men independently from compliance to CPAP use, but not in women Guasti et al [44 ] TNF-α 12 weeks TNF-α and IL-8 levels remained unchanged after treatment Ohga et al. [48 ] IL-8 8–18 months IL-8 and ICAM-1 levels were decreased after treatment Oyama et al. [49 ] TNF-α 3 months TNF-α , IL-8, and IL-6 levels were decreased after treatment Chin et al. [67 ] VCAM-1 3-4 days, After 1 month E-selectin and ICAM-1 levels but not VCAM-1 had decreased.
