Muscle-Specific PPAR<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>β</mml:mi><mml:mtext>/</mml:mtext><mml:mi>δ</mml:mi></mml:mrow></mml:math>
 Agonism May Provide Synergistic Benefits with Life Style Modifications

Erol, Adnan

doi:https://doi.org/10.1155/2007/30578

PPAR Research

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Volume 2007 | Article ID 030578 | https://doi.org/10.1155/2007/30578

Muscle-Specific PPARβ/δ Agonism May Provide Synergistic Benefits with Life Style Modifications

Adnan Erol¹

Academic Editor: Jihan Youssef

Received02 Jul 2007

Revised08 Aug 2007

Accepted13 Nov 2007

Published12 Dec 2007

Abstract

Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) has emerged as a powerful metabolic regulator in diverse tissues including fat, skeletal muscle, and the heart. It is now established that activation of PPARβ/δ promotes fatty acid oxidation in several tissues, such as skeletal muscle and adipose tissue. In muscle, PPARβ/δ appears to act as a central regulator of fatty acid catabolism. PPARβ/δ contents are increased in muscle during physiological situations such as physical exercise or long-term fasting, characterized by increased fatty acid oxidation. Targeted expression of an activated form of PPARβ/δ in skeletal muscle induces a switch to form increased numbers of type I muscle fibers resembling the fiber type transition by endurance training. Activation of PPARβ/δ also enhances mitochondrial capacity and fat oxidation in the skeletal muscle that resembles the effect of regular exercise. Therefore, it is hypothesized that muscle-specific PPARβ/δ agonists could be a key strategy to support the poor cardiorespiratory fitness associated with metabolic disorders.

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Copyright © 2007 Adnan Erol. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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