Nuclear Receptor Cofactors in PPAR<mml:math id="E1" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>γ</mml:mi></mml:math>-Mediated Adipogenesis and Adipocyte Energy Metabolism

Powell, Emily; Kuhn, Peter; Xu, Wei

doi:https://doi.org/10.1155/2007/53843

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PPARS and Obesity

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Volume 2007 | Article ID 053843 | https://doi.org/10.1155/2007/53843

Nuclear Receptor Cofactors in PPARγ-Mediated Adipogenesis and Adipocyte Energy Metabolism

Emily Powell,¹Peter Kuhn,¹and Wei Xu¹

Academic Editor: Francine M. Gregoire

Received14 Jul 2006

Revised17 Oct 2006

Accepted17 Oct 2006

Published19 Dec 2006

Abstract

Transcriptional cofactors are integral to the proper function and regulation of nuclear receptors. Members of the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors are involved in the regulation of lipid and carbohydrate metabolism. They modulate gene transcription in response to a wide variety of ligands, a process that is mediated by transcriptional coactivators and corepressors. The mechanisms by which these cofactors mediate transcriptional regulation of nuclear receptor function are still being elucidated. The rapidly increasing array of cofactors has brought into focus the need for a clear understanding of how these cofactors interact in ligand- and cell-specific manners. This review highlights the differential effects of the assorted cofactors regulating the transcriptional action of PPARγ and summarizes the recent advances in understanding the physiological functions of corepressors and coactivators.

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Copyright © 2007 Emily Powell et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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