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PPAR Research
Volume 2007 (2007), Article ID 61563, 10 pages
http://dx.doi.org/10.1155/2007/61563
Review Article

Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation

1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston 77030, TX, USA
2Department of Biological Sciences, Northern Kentucky University, Highland Heights 41099, KY, USA

Received 30 April 2007; Accepted 11 June 2007

Academic Editor: Jeffrey M. Gimble

Copyright © 2007 Eimear M. Mullen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Embryonic stem (ES) cells have great therapeutic potential because they are capable of indefinite self-renewal and have the potential to differentiate into over 200 different cell types that compose the human body. The switch from the pluripotent phenotype to a differentiated cell involves many complex signaling pathways including those involving LIF/Stat3 and the transcription factors Sox2, Nanog and Oct-4. Many nuclear receptors play an important role in the maintenance of pluripotence (ERRβ, SF-1, LRH-1, DAX-1) repression of the ES cell phenotype (RAR, RXR, GCNF) and also the differentiation of ES cells (PPARγ). Here we review the roles of the nuclear receptors involved in regulating these important processes in ES cells.