The Role of PPARs in Cancer

Table 1

Summary of the species differences of PPAR.

	Human	Rodent
PPAR expression levels	+	++
PPAR variants	Yes	?
Peroxisome proliferation	+/𝛼	+
Fatty acid metabolism	+	+
Expression of cell cycle regulator genes	+/𝛼	+
Expression of miRNA (let-7C)	+	𝛼
Hepatocellular proliferation	+/𝛿	+
Apoptosis	+	𝛿
Liver tumor	+/𝛾	++