Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism

Figure 2

The PPAR𝛼 agonist Wy14643 prevents the fasting-induced increase in liver TG levels. Male wild-type and PPAR𝛼 null mice (𝑛=5 per group) were given vehicle or Wy14643 for 10 days (0.1% mixed in their food). After a 24-hour fast, livers were dissected and stained histochemically using hematoxylin/eosin (a) or oil Red O (b). Representative livers sections are shown. Differences visualized by histochemistry were perfectly confirmed by quantitative measurement of hepatic TG levels.

(a)

(b)