| | Ligands | Nature | Affinity | Clinical status |
| | Natural agonists | | | | | Linoleic acid | Dietary fatty acid | M | | Oleic acid | Dietary fatty acid | M | | Arachidonic acid | Dietary fatty acid | M | | Eicosapentaenoic acid | Dietary fatty acid | M | | Docosahexaenoic acid | Dietary fatty acid | M | | Prostaglandin A1 | Endogenous prostaglandin | M | | Synthetic agonists | | | | | Carbaprostacyclin | Synthetic stable PGI2 analogue | M | | Iliprost | Prostacyclin analogue | M | | Compound F | Phenoxyacetic acid derivative | nM | | L165,041 | Phenoxyacetic acid derivative | nM | | GW501516 | Phenoxyacetic acid derivative | nM | | GW0742 | Phenoxyacetic acid derivative | nM | | KD2010 | not disclosed | nM | Phase I | | MBX-8025 | not disclosed | nM | Phase II | | Synthetic dual agonists | | | | | Compound 23 | Dual agonist for and | nM | | Synthetic antagonist | | | | | GSK0660 | Antagonist for | nM |
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