Synergistic Effects of PPAR<svg     style="vertical-align:-4.698pt;width:11.35px;" id="M1" height="16.012501" version="1.1" viewBox="0 0 11.35 16.012501" width="11.35"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,10.1)"><path id="x1D6FE" d="M478 372q0 -39 -31 -97t-61 -98t-78 -98q-45 -55 -73 -102q-13 -79 -13 -197q-11 -11 -43.5 -25.5t-53.5 -15.5l-15 17q5 35 26 101.5t47 123.5q8 72 -1.5 174.5t-37.5 178.5q-14 37 -29 37q-20 0 -67 -65l-25 21q37 60 73 90.5t63 30.5q47 0 72 -112q13 -56 17.5 -141.5
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</svg> Ligands and Retinoids in Cancer Treatment

<table>
PPAR activation
pathway and transcriptional regulation of target genes.  After ligand binding, PPARs form heterodimers
with RXR in the nucleus. The PPAR/RXR
heterodimers interact with transcriptional coactivators (CoActs) and bind to
sequence specific PPRE located in the target genes that control glucose and
insulin homeostasis, lipid metabolism, inflammation, and cellular
differentiation. L: ligand.</table>

PPAR Research

fig1

Figure 1

Figure 1: Synergistic Effects of PPAR<svg     style="vertical-align:-4.698pt;width:11.35px;" id="M1" height="16.012501" version="1.1" viewBox="0 0 11.35 16.012501" width="11.35"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,10.1)"><path id="x1D6FE" d="M478 372q0 -39 -31 -97t-61 -98t-78 -98q-45 -55 -73 -102q-13 -79 -13 -197q-11 -11 -43.5 -25.5t-53.5 -15.5l-15 17q5 35 26 101.5t47 123.5q8 72 -1.5 174.5t-37.5 178.5q-14 37 -29 37q-20 0 -67 -65l-25 21q37 60 73 90.5t63 30.5q47 0 72 -112q13 -56 17.5 -141.5
t0.5 -143.5h2q155 193 155 297q0 26 -12 47q-5 8 -5 15q0 16 12.5 27t29.5 11q21 0 34 -21t13 -55z" /></g>

		
	
</svg> Ligands and Retinoids in Cancer Treatment 

PPAR Research

Synergistic Effects of PPAR Ligands and Retinoids in Cancer Treatment

Figure 1