To Live or to Die: Prosurvival Activity of PPAR𝜸 in Cancers

Table 3

Points to be considered to discern drugs/TZDs versus receptor effects.

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(1) Are high or low doses of drugs used in the studies with respect to their K_d values for PPAR𝛾, or plasma concentrations?

(2) Are multiple pharmacological agents of different chemical classes used?

(3) Are any antagonists included in the study?

(4) Are any genetic approaches used to confirm the pharmacological findings?

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