Research Article

Genetic Polymorphisms of Peroxisome Proliferator-Activated Receptors and the Risk of Cardiovascular Morbidity and Mortality in a Community-Based Cohort in Washington County, Maryland

Table 2

The associations between PPAR SNPs and cardiovascular risk factors. Goodness of fit likelihood ratio P value using logistic regression modeling adjusted for age; P value for age based on Student’s -test. Combined outcomes had condition at baseline or reported on followup questionnaires (for diabetes, self-reported on followup questionnaires only).
(a)

Risk factorsPPARG rs4684847PPARG rs709158PPARG 1175543

CC CT/ TTP value AA AG/GGP value AA AG/GGP value

Baseline characteristics
Age, mean(SD)53.0 (15.5)53.4 (15.4).357152.7 (15.4)53.3 (15.4).078052.9 (15.5)53.3 (15.3).1910
BMI, kg/m2, n (%).0203.8458.9777
<253097 (79)815 (21)1562 (40)2372 (60) 1575 (40) 2366 (60)
25–302645 (78)745 (22)1392 (40) 2048 (60) 1393 (41) 2037 (59)
>301331 (76)412 (24)681 (39)1067 (61)696 (40)1059 (60)

Cholesterol no Rx, mg/dL, .7144.0370.0198
n (%)
≤200 2956 (79)791 (21)1469 (39) 2295 (61)1481 (39)2284 (61)
200–2392443 (78) 702 (22) 1274 (40)1897 (60) 1281 (40)1904 (60)
≥2401275 (79)346 (21)674 (41)964 (59)688 (42)943 (58)

Cholesterol with Rx, mg/dL, .8997.4595.3418
n (%)
≤200 82 (76)26 (24)40 (36)71 (64) 37 (34)71 (66)
200–239141 (74)50 (26)78 (39)121 (61) 79 (40)119 (60)
≥240125 (75)42 (25)70 (41)102 (59)70 (41)102 (59)

Blood pressure, n (%) .0248.0513.0509
Normal 1777 (79)460 (21) 875 (39) 1369 (61) 882 (39)1362 (61)
Prehypertensive4290 (78)1193 (22)2209 (40) 3338 (60)2221 (40)3322 (60)
Hypertensive1005 (76)320 (24)549 (41)782 (59)561 (42)779 (58)

Combined outcomes
Diabetes, n (%) .7845.8617.5499
No4504 (78)1243 (22)2325 (40)3466 (60)2350 (41) 3451 (59)
Yes821 (78)225 (22)420 (40)643 (60)418 (39)648 (61)

High cholesterol, n (%) .3452.4527.5670
No2502 (78)706 (22)1280 (40)1944 (60)1296 (40)1938 (60)
Yes2712 (79)730 (21)1408 (40)2081 (60)1414 (41)2075 (59)

High blood pressure, n (%) .6258.2150.2724
No 2441 (79)660 (21) 1287 (41)1834 (59)1293 (41) 1829 (59)
Yes3379 (78)969 (22)1720 (39)2675 (61)1741 (40)2663 (60)

(b)

Risk factorsPPARD rs2016520PPARG rs1801282

CC CT/TTP value Pro/Pro Pro/Ala or Ala/AlaP value

Age, mean(SD)53.0 (15.4)53.0 (15.5).964052.9 (15.4)53.2 (15.3).4587
BMI, kg/m2, n (%) .9138.1280
<252534 (64)1389 (36)3085 (79)832 (21)
25–302190 (64)1246 (36)2668 (78)757 (22)
>301136 (65)609 (35)1346 (77)403 (23)

Cholesterol no Rx, mg/dL, n (%) .0161.7401
≤2002475 (66) 1290 (34)2953 (78) 811 (22)
200–239 2011 (63)1161 (37)2467 (78) 705 (22)
≥2401019 (63)604 (37)1261 (78)354 (22)

Cholesterol with Rx, mg/dL, n (%) .3821.6233
≤200 74 (67) 37 (33) 86 (80) 22 (20)
200–239135 (69) 62 (31) 148 (76) 48 (24)
≥240106 (63)63 (37)128 (76)40 (24)

Blood pressure, n (%) .8076.2636
Normal1441 (64)812 (36) 1769 (79)483 (21)
Prehypertensive3578 (65) 1939 (35) 4312 (78)1199 (22)
Hypertensive842 (63)491 (37)1016 (77)312 (23)

Combined outcomes
Diabetes, n (%) .6185.1278
No 3747 (65) 2058 (35) 4517 (78) 1275 (22)
Yes675 (64)383 (36)841 (80)212 (20)

High cholesterol, n (%) .3178.3691
No2060 (64)1175 (36) 2516 (78)713 (22)
Yes2263 (65)1225 (35)2732 (79)740 (21)

High blood pressure, n (%) .9412.8331
No 2006 (64) 1121 (36) 2462 (78)676 (22)
Yes2821 (64)1564 (36)3384 (78)971 (22)