PPAR Research / 2008 / Article / Tab 2 / Research Article
Genetic Polymorphisms of Peroxisome Proliferator-Activated Receptors and the Risk of Cardiovascular Morbidity and Mortality in a Community-Based Cohort in Washington County, Maryland Table 2 The associations between PPAR SNPs and cardiovascular risk factors. Goodness of fit
likelihood ratio
P value using logistic regression modeling adjusted for
age;
P value for age based on Student’s
-test. Combined outcomes had
condition at baseline or reported on followup questionnaires (for diabetes,
self-reported on followup questionnaires only).
(a) Risk factors PPARG rs4684847PPARG rs709158PPARG 1175543 CC CT/ TT P value AA AG/GG P value AA AG/GG P valueBaseline characteristics Age, mean(SD) 53.0 (15.5) 53.4 (15.4) .3571 52.7 (15.4) 53.3 (15.4) .0780 52.9 (15.5) 53.3 (15.3) .1910 BMI, kg/m2 , n (%) .0203 .8458 .9777 <25 3097 (79) 815 (21) 1562 (40) 2372 (60)
1575 (40) 2366 (60) 25–30 2645 (78) 745 (22) 1392 (40) 2048 (60) 1393 (41)
2037 (59) >30 1331 (76) 412 (24) 681 (39) 1067 (61) 696 (40) 1059 (60) Cholesterol no Rx, mg/dL,
.7144 .0370 .0198 n
(%)≤200
2956 (79) 791 (21) 1469 (39) 2295 (61) 1481 (39) 2284 (61) 200–239 2443 (78) 702 (22)
1274 (40) 1897 (60) 1281 (40) 1904 (60) ≥240 1275 (79) 346 (21) 674 (41) 964 (59) 688 (42) 943 (58) Cholesterol with Rx, mg/dL,
.8997 .4595 .3418 n (%)
≤200
82 (76) 26 (24) 40 (36) 71 (64)
37 (34) 71 (66) 200–239 141 (74) 50 (26) 78 (39) 121 (61) 79 (40) 119 (60) ≥240 125 (75) 42 (25) 70 (41) 102 (59) 70 (41) 102 (59) Blood pressure, n (%) .0248 .0513 .0509 Normal
1777 (79) 460 (21)
875 (39) 1369 (61) 882 (39) 1362 (61)
Prehypertensive 4290 (78) 1193 (22) 2209 (40)
3338 (60) 2221 (40) 3322 (60) Hypertensive 1005 (76) 320 (24) 549 (41) 782 (59) 561 (42) 779 (58) Combined outcomes Diabetes, n (%)
.7845 .8617 .5499 No 4504 (78) 1243 (22) 2325 (40) 3466 (60) 2350 (41) 3451 (59)
Yes 821 (78) 225 (22) 420 (40) 643 (60) 418 (39) 648 (61) High cholesterol, n (%)
.3452 .4527 .5670 No 2502 (78) 706 (22) 1280 (40) 1944 (60) 1296 (40) 1938 (60)
Yes 2712 (79) 730 (21) 1408 (40) 2081 (60) 1414 (41) 2075 (59) High blood pressure, n (%) .6258 .2150 .2724 No
2441 (79) 660 (21)
1287 (41) 1834 (59) 1293 (41) 1829 (59) Yes 3379 (78) 969 (22) 1720 (39) 2675 (61) 1741 (40) 2663 (60)
(b) Risk factors PPARD rs2016520PPARG rs1801282 CC CT/TT P value Pro/Pro Pro/Ala or
Ala/Ala P valueAge, mean(SD) 53.0 (15.4) 53.0 (15.5) .9640 52.9 (15.4) 53.2 (15.3) .4587 BMI, kg/m2 , n
(%)
.9138 .1280 <25 2534 (64) 1389 (36) 3085 (79) 832 (21)
25–30 2190 (64) 1246 (36) 2668 (78) 757 (22) >30 1136 (65) 609 (35) 1346 (77) 403 (23) Cholesterol no Rx, mg/dL, n
(%)
.0161 .7401 ≤200 2475 (66)
1290 (34) 2953 (78)
811 (22)
200–239
2011 (63) 1161 (37) 2467 (78) 705 (22) ≥240 1019 (63) 604 (37) 1261 (78) 354 (22) Cholesterol with Rx, mg/dL,
n (%)
.3821 .6233 ≤200
74 (67) 37 (33) 86 (80)
22 (20) 200–239 135 (69)
62 (31)
148 (76) 48 (24) ≥240 106 (63) 63 (37) 128 (76) 40 (24) Blood pressure, n (%)
.8076 .2636 Normal 1441 (64) 812 (36) 1769 (79) 483 (21) Prehypertensive 3578 (65)
1939 (35)
4312 (78) 1199 (22) Hypertensive 842 (63) 491 (37) 1016 (77) 312 (23) Combined outcomes Diabetes, n (%) .6185 .1278 No
3747 (65) 2058 (35)
4517 (78)
1275 (22) Yes 675 (64) 383 (36) 841 (80) 212 (20) High cholesterol, n (%)
.3178 .3691 No 2060 (64) 1175 (36) 2516 (78) 713 (22) Yes 2263 (65) 1225 (35) 2732 (79) 740 (21) High blood pressure, n (%) .9412 .8331 No
2006 (64) 1121 (36)
2462 (78) 676 (22) Yes 2821 (64) 1564 (36) 3384 (78) 971 (22)