Statins Activate Human PPAR Promoter and Increase PPAR mRNA Expression and Activation in HepG2 Cells
Figure 2
PPAR mRNA expression in HepG2 cells after treatment
with atorvastatin (Ator), cerivastatin (Ceri), fluvastatin (Flu), pitavastatin
(Pita), pravastatin (Pra), rosuvastatin (Rosu), and simvastatin (Sim) for 24
hours. (a) Each statin was used at concentrations of 5, 10, and
. Nontreated cells (statin concentration ) were the control. (b) Pravastatin was used
at higher concentrations of 20, 50, 100, and
. Nontreated cells (pravastatin concentration ) were the control. The data are expressed as
% of controls. Values are presented as the mean SEM of three separate experiments, significantly
different from control at , .
