The Role of PPAR-𝜸 and Its Interaction with COX-2 in Pancreatic Cancer

Figure 1

Possible interactions between the COX-2 and PPAR-γ pathways: polyunsaturated fatty acids (PUFAs) are substrates for cyclooxygenase-2 (COX-2) enzymes leading to the formation of various prostaglandins (PGs). Certain PUFAs and PGs can also activate PPAR-γ. Selective and nonselective COX-2 inhibitors (COX Inh) block PG formation by COX-2 but can also at higher concentrations activate PPAR-γ. Solid arrows indicate activation; dashed arrow indicates metabolic pathway; blocked arrow indicates inhibition.