Peroxisome Proliferator-Activated Receptor- in Amyotrophic Lateral Sclerosis and Huntington's Disease
Figure 1
(a) Structure of PPAR agonists, (b) schematic diagrams linking mechanisms of neuronal
cell death in ALS and a representation of PPAR-γ activation. The mechanisms and pathways implicated in the pathogenesis of ALS that lead to the
demise of motor neurons are multiple. Activation of PPAR-γ by pioglitazone has the
potential to block inflammatory pathway via the upregulation of anti-inflammatory
genes and downregulation of proinflammatory genes. The transcription of PPAR-γ target
gene regulation occurs when ligand binds to PPAR-γ and PPAR-γ-RXR heterodimers
formed, then it binds to PPRE of DNA of target gene.
