Transcriptional Control of Vascular Smooth Muscle Cell Proliferation by Peroxisome Proliferator-Activated Receptor-: Therapeutic Implications for Cardiovascular Diseases
Figure 1
Cellular mechanisms
involved in the inhibition of SMC proliferation by PPAR during cardiovascular diseases. PPAR
regulates genes encoding proteins involved in diverse SMC processes including
cell proliferation, cell-cycle progression, senescence, and apoptosis.