]>Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>γ</mml:mi></mml:math> Agonist : Table 4
Table 4: Differential activation of PPAR-γ by PPAR-γ agonists in the presence of 10% of human, rat, and mouse serum. Values are EC50 ( 𝜇 M) determined from 3 experiments and shown as the mean ± SD. FC is the ratio of EC50s for human: rat or human: mouse (* = 𝑃 < . 0 5 , ** = 𝑃 < . 0 1 , *** = 𝑃 < . 0 0 1 by ANOVA with Tukey post hoc test).
PPAR agonist Mean EC50 ( 𝜇 M) ± SD Fold Change in EC50
Human Rat Mouse Human:Rat Human:Mouse
MBX-102 acid 260 ± 16.9 196 ± 18 169 ± 5.2 1.33** 1.53***
Rosiglitazone 2 . 0 ± 0 . 1 5 . 2 ± 0 . 3 4 . 5 ± 0 . 3 0.39*** 0.45***
Pioglitazone 8 . 3 ± 0 . 4 1 1 . 4 ± 1 . 2 9 . 7 ± 1 . 4 0.73NS 0.86NS