Potential Therapeutic Use of PPAR𝛾-Programed Human Monocyte-Derived Dendritic Cells in Cancer Vaccination Therapy

Figure 1

General scheme of anticancer vaccination. Dendritic cell progenitors (either CD34⁺ or CD14⁺ cells) are obtained using cytopheresis. Cells are differentiated using cytokines GM-CSF and IL-4. Immature dendritic cells are loaded with tumor lysate, peptides, or expression vector. DC maturation is induced and DCs are reinjected to patient.