Review Article
Potential Therapeutic Targets for PPAR after Spinal Cord Injury
Table 1
Summary of effects mediated by PPAR activation in CNS injury or disease models.
| Disease/injury model | Known PPAR effects | References |
| Spinal cord injury | locomotor recovery | [15, 16] | myelin sparing | motor
neuron sparing | glial
activation | proinflammatory
cytokines |
| Experimental allergic encephalomyelitis (model of multiple sclerosis) | myelin sparing
| [33, 44, 48, 61] | lesion size | inflammatory cell infiltrate | proinflammatory
cytokines & chemokines | clinical score (better recovery; lower no. of relapses) |
| Amyotrophic lateral
sclerosis | motor
neuron survival
| [32] | glial
activation | COX-2 | iNOS | longevity, delayed disease onset |
| Parkinsonโs disease | dopaminergic
neuron survival | [43, 46] | gliosis | iNOS | NFB translocation to the nucleus | IB |
| Cerebral ischemia | neuron survival in penumbra | [6, 31, 35, 37, 64] | lesion size | COX-2 | proinflammatory cytokines | antioxidants |
| Cerebral hemorrhage | catalase | [38] | NFB | neutrophil infiltration | apoptosis | behavioral dysfunction |
| Alzheimer's disease | gliosis | [7, 45, 65, 66] | COX-2 & iNOS | proinflammatory
cytokines | A1-42+
amyloid plaques | -secretase
mRNA | monocyte differentiation into macrophages |
|
|