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Table 5: PPAR in pregnancy-specific diseases.

PPAR PPAR-action Disease Model Reference PPARγ Reduced circulating PPARγ activators in serum from women with PE PE In vitro Waite et al. [111] Placental 15dPGJ2level are decreased in diabetes GDM Murine Capobianco et al. [95] Association of PPAR-γ2 Pro12Ala with weight gain GDM Human Tok et al. [112] Placental 15dPGJ2levels are decreased GDM Human Javerbaum et al. [113] Decreased Hydatidiform mole Human Capparuccia et al. [114] Decreased Choriocarcinoma Human Capparuccia et al. [114] Placental PPAR expression is not involved IUGR Human Rodie et al. [115] Association of PPAR-γ2 Pro12Ala polymorphism Preterm birth Human Meirhaeghe et al. [116] PPARα Lack of PPAR-α upregulates Th1 cytokines Abortion/neonatal mortality Murine Yessoufou et al. [76]