Peroxisome Proliferator-Activated Receptors: “Key” Regulators of Neuroinflammation after Traumatic Brain Injury

<table><i>Mechanism of gene transcription
through ligand binding on peroxisome proliferator-activated receptors (PPARs)</i>. In presence of coactivating stimuli, PPARs heterodimerize with retinoid
X receptors (RXR) to form active transcription factors. The DNA binding domain
on PPAR-RXR heterodimers induces the transcription of target genes by binding
to peroxisome proliferator-response elements (PPRE's) which consist of
DNA-specific sequences.</table>

PPAR Research

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Figure 1

Figure 1: Peroxisome Proliferator-Activated Receptors: “Key” Regulators of Neuroinflammation after Traumatic Brain Injury 