PPAR Alpha Regulation of the Immune Response and Autoimmune Encephalomyelitis
Figure 1
A model for PPAR--mediated protection in EAE.
In the presence of PPAR- agonists, PPAR- heterodimerizes with RXR, dissociates from its nuclear corepressor complex, associates with a coactivator complex, and binds to PPREs in the promoter region of IL-4 and/or IL-5. The transactivation of IL-4/IL-5 leads to increased expression of GATA-3 which in turn results in decreased T-bet expression and downregulation of the Th1/Th17 inflammatory response. This shift in the immune response to a Th2-like phenotype results in amelioration of EAE.