PPAR Regulation of Inflammatory Signaling in CNS Diseases

Figure 3

Regulation of NF-𝜅B pathway by PPAR agonists in CNS diseases. The activation of microglia, macrophage and dendritic cells through toll-like receptor, CD40 or cytokine associated NF-𝜅B pathway leads to secretion of inflammatory cytokines leading to pathogenesis of CNS diseases. PPAR agonists inhibit NF-𝜅B pathway resulting in inhibition of CNS diseases.