Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template
Figure 10
Predicted
mode of binding of TIPP-401 to PPAR and PPAR.
Upper
figures represent van der Waals surface contact of ligand-binding cavity, and
the lower figure represent detailed component aminoacids.