Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template
Figure 8
Predicted mode of binding the amide derivative and the reversed-amide derivative to PPAR. Orange: hydrophobic aminoacids. Green: hydrophilic aminoacids. Magenta: amide derivative and reversed-amide derivative. Hydrogen bonds are shown as yellow dotted lines.
