Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template
Figure 9
Comparison of the CoMFA counterplot of the steric field based on TIPP-401 (right) and the superimposition of TIPP-401 on the ligand-binding domain of PPAR (left).
The CoMFA steric counter map is shown in green and yellow. Green: areas in which bulky atomic groups are sterically favorable for the activity. Yellow: areas in which bulky atomic groups are unfavorable for the activity.
