Review Article
PPAR and Apoptosis in Cancer
Table 1
PPAR agonists induce apoptosis in cancer.
| PPAR agonist | PPAR | Tumor type | Molecular mediator(s) of apoptosis | Reference |
| 15d-PGJ2 | Independent | Breast | Unknown | [8] | Troglitazone and 15d-PGJ2 | Dependent | Thyroid | c-myc | [9] | Ciglitazone | Dependent | Thyroid | PPAR | [10] | Rosiglitazone | Dependent | Thyroid | NF-B, cyclinD1, caspase-3 | [11] | Troglitazone and 15d-PGJ2 | Unknown | Colon | c-myc, c-jun, GADD153 | [12] | Troglitazone | Dependent | Lung | GADD153 | [13] | Troglitazone | Independent | Colon | EGR-1, NAG-1 | [14, 15] | 15d-PGJ2 | Dependent | Colon | EGR-1, NAG-1 | [15] | Troglitazone | Dependent | Lung | ERK1/2 | [16] | Troglitazone | Dependent and independent | Colon | p53, POX | [17] | Troglitazone | Independent | Prostate | Bcl-2, Bcl-XL | [18] | 15d-PGJ2 | Independent | Oral | Stat3 | [19] | 15d-PGJ2 | Independent | Prostate, bladder | Caspase-3, -7 | [20] | 15d-PGJ2 | Independent | Multiple myeloma, burkitt
lymphoma | NF-kappa-B, cIAP-1, XIAP, c-FLIP | [21] | Rosiglitazone | Dependent | Breast | PPAR, p53 | [22] |
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